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Ein ganz verrückter Freitag |
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| 1977 | Taxi Driver | Gewonnen | National Society of Film Critics Awards, USA | NSFC Award | Best Supporting Actress |
| 1977 | Taxi Driver | Gewonnen | BAFTA Awards | BAFTA Film Award | Best Supporting Actress |
| 1977 | Taxi Driver | Gewonnen | BAFTA Awards | BAFTA Film Award | Best Newcomer |
| 1978 | The Little Girl Who Lives Down the
Lane, Das Mädchen am Ende der Straße |
Gewonnen | Academy of Science Fiction, Fantasy & Horror Films, USA | Saturn Award | Best Actress - Horror |
| 1981 | Foxes, Jeanies Clique |
Nominiert | Young Artist Awards | Young Artist Award | Best Young Actress in a Major Motion Picture |
| 1989 | Five Corners | Gewonnen | Independent Spirit Awards | Independent Spirit Award | Best Female Lead |
| 1988 | The Accused, Angeklagt |
Gewonnen | National Board of Review, USA | NBR Award | Best Actress |
| 1989 | The Accused, Angeklagt |
Gewonnen | Academy Awards, USA | Oscar | Best Actress in a Leading Role |
| 1989 | The Accused, Angeklagt |
Gewonnen | David di Donatello Awards | David | Best Foreign Actress (Migliore Attrice Straniera) |
| 1989 | The Accused, Angeklagt |
Gewonnen | Golden Globes, USA | Golden Globe | Best Performance by an Actress in a Motion Picture - Drama |
| 1990 | The Accused, Angeklagt |
Nominiert | BAFTA Awards | BAFTA Film Award | Best Actress |
| 1991 | Gewonnen | Boston Film Festival | Film Excellence Award | Film Excellence Award | |
| 1991 | The Silence of the Lambs, Das Schweigen der Lämmer |
Gewonnen | New York Film Critics Circle Awards | NYFCC Award | Best Actress |
| 1992 | The Silence of the Lambs, Das Schweigen der Lämmer |
Gewonnen | Academy Awards, USA | Oscar | Best Actress in a Leading Role |
| 1992 | The Silence of the Lambs, Das Schweigen der Lämmer |
Gewonnen | BAFTA Awards | BAFTA Film Award | Best Actress |
| 1992 | The Silence of the Lambs, Das Schweigen der Lämmer |
Gewonnen | Golden Globes, USA | Golden Globe | Best Performance by an Actress in a Motion Picture - Drama |
| 1992 | The Silence of the Lambs, Das Schweigen der Lämmer |
Nominiert | London Critics Circle Film Awards | ALFS Award | Actress of the Year |
| 1992 | Gewonnen | Hasty Pudding Theatricals, USA | Woman of the Year | Woman of the Year | |
| 1994 | Nell | Nominiert | ShoWest Convention, USA | ShoWest Award | Female Star of the Year |
| 1995 | Nell | Nominiert | Academy Awards, USA | Oscar | Best Actress in a Leading Role |
| 1995 | Nell | Gewonnen | David di Donatello Awards | David | Best Foreign Actress (Migliore Attrice Straniera) |
| 1995 | Nell | Nominiert | Golden Globes, USA | Golden Globe | Best Performance by an Actress in a Motion Picture - Drama |
| 1995 | Nell | Nominiert | MTV Movie Awards | MTV Movie Award | Best Female Performance |
| 1995 | Nell | Gewonnen | Screen Actors Guild Awards | Actor | Outstanding Performance by a Female Actor in a Leading Role |
| 1995 | Gewonnen | People's Choice Awards, USA | People's Choice Award | Favorite Dramatic Motion Picture Actress | |
| 1995 | Gewonnen | Southeastern Film Critics Association Awards | SEFCA Award | Best Actress | |
| 1996 | Gewonnen | American Society of Cinematographers, USA | |||
| 1996 | Gewonnen | Berlin International Film Festival | Berlinale Camera | Berlinale Camera | |
| 1996 | Gewonnen | Golden Camera, Germany | Golden Camera | Golden Camera | |
| 1996 | Gewonnen | Women in Film Crystal Awards | Crystal Award | Crystal Award | |
| 1997 | Gewonnen | European Film Awards | Audience Award | Best Actress | |
| 1997 | Gewonnen | FilmFest Hamburg | Douglas Sirk Award | Douglas Sirk Award | |
| 1997 | Gewonnen | Golden Satellite Awards | Mary Pickford Award | Mary Pickford Award | |
| 1998 | Contact | Gewonnen | Academy of Science Fiction, Fantasy & Horror Films, USA | Saturn Award | Best Actress |
| 1998 | Contact | Nominiert | Blockbuster Entertainment Awards | Blockbuster Entertainment Award | Favorite Actress - Drama |
| 1998 | Contact | Nominiert | Golden Globes, USA | Golden Globe | Best Performance by an Actress in a Motion Picture - Drama |
| 1998 | Contact | Gewonnen | Rembrandt Awards | Audience Award | Best Actress |
| 1999 | The Baby Dance | Nominiert | Emmy Awards | Emmy | Outstanding Made for Television Movie |
| 1999 | Gewonnen | American Cinematheque Gala Tribute | |||
| 2002 | Gewonnen | Hollywood Film Festival | Hollywood Discovery Award | Outstanding Achievement in Acting | |
| 2003 | Panic Room | Nominiert | Academy of Science Fiction, Fantasy & Horror Films, USA | Saturn Award | Best Actress |
| 2006 | Flightplan | Nominiert | Academy of Science Fiction, Fantasy & Horror Films, USA | Saturn Award | Best Actress |
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